In vitro evaluation of antiprotozoal and antiviral activities of extracts from argentinean mikania species

LAURELLA LC, FRANK FM, SARQUIZ A, ALONSO MR, GIBERTI G, CAVALLARO L, CATALÁN CA, CAZORLA SI, MALCHIODI E, MARTINO VS, SÜLSEN VP.

Scientific World journal

Boynton Beach, FL : Scientific World, Inc., c2001

Lugar: England; Año: 2012 vol. 2012 p. 121253 - 121259

1537-744X

The aim of this study was to investigate the antiprotozoal and antiviral activities of four Argentinean Mikania species. The organic and aqueous extracts of Mikania micrantha, M. parodii, M. periplocifolia, and M. cordifolia were tested on Trypanosoma cruzi epimastigotes, Leishmania braziliensis promastigotes, and dengue virus type 2. The organic extract of M. micrantha was themost active against T. cruzi and L. braziliensis exhibiting a growth inhibition of 77.6 ± 4.5% and 84.9 ± 6.1%, respectively, at a concentration of 10 μg/ml. The bioguided fractionation of M. micrantha organic extract led to the identification of two active fractions. The chromatographic profile and infrared analysis of these fractions revealed the presence of sesquiterpene lactones. None of the tested extracts were active against dengue virus type 2.