Current scenario of plasmid-mediated colistin resistance in Latin America

CECILIA QUIROGA; MARCELA NASTRO; JOSÉ DI CONZA

REVISTA ARGENTINA DE MICROBIOLOGíA

ASOCIACION ARGENTINA MICROBIOLOGIA

Año: 2018

0325-7541

Colistin resistance can occur by chromosomal mutations and by acquisition ofplasmid-carrying determinants, mainly mcr-1. In the recent years, we have observed the outburstof this resistance gene in our region. Due to the risk of the rapid dissemination of mcr-1,this finding has worried and alerted different actors from the health field and has become oneof the most prolific topics. Our review compiles available reports of well-documented mcr-1-positive strains of Enterobacteriaceae, obtained from different samples in Argentina andother countries of Latin America. Furthermore, it addresses the association of mcr-1 with ESBLresistance markers and outlines the platforms involved in their dissemination