congresos y reuniones científicas
Declarative memory consolidation dynamics: new time windows and its implications for clinical application.
MALEN MOYANO; MATÍAS BONILLA; MF BLANCO; IGNACIO BRUSCO; MARÍA EUGENIA PEDREIRA; LAURA KACZER; CECILIA FORCATO
Congreso; XXXV Anual Virtual Meeting of the Argentinean Society of Neuroscience; 2020
After encoding, memories are in a labile state followed by a stabilization process knownas consolidation. Spontaneous reactivation occurs during sleep and wakefulness(without the re-exposure to keys linked to learning). Here, we investigate whetherdeclarative memories in humans suffer spontaneous labilization/stabilization processesafter learning or if they only pass through a single time window of lability. Participantslearned a list of five pairs of non-sense syllables on day 1. Immediately after, 30 min or3 hours later they received an interference list that acted as an amnesic agent. Theywere finally tested on day 3. The two control groups were only trained and tested inone of the tasks. We found that the interference task learned at usual times afterlearning (immediately and 3 h latter) impaired memory stabilization, however, 30 minafter it has no impairing effects. Thus, immediately after learning the memory is labile, itpasses through a rapid stabilization 30 min later where it is temporally protectedagainst interference and it becomes labile again around 3 h later. Thus, the dynamicsof the declarative memory consolidation seems not to be an all or nothing process.Further studies should be done to test if similar waves of lability exist after cuedmemory reactivation. Knowing the different time windows susceptible to interferencesbecomes fundamental for the design of new psychotherapy treatments for anxietydisorders such as phobias.