congresos y reuniones científicas
Cued memory reactivation is more effective during slow wave sleep than sleep stage 2
CARBONE JULIA; CECILIA FORCATO; JAN BORN; SUSANNE DIEKELMANN
Congreso; FENS; 2020
Sleep plays a central role in memory formation, being particularly important for theconsolidation of new information and its long-term storage. Following a learning experience,spontaneous memory reactivations occur during sleep, particularly during slow wave sleep(SWS), and are assumed to underlie the memory effect of sleep. Memory reactivation can alsobe externally stimulated during sleep through the presentation of reminder cues. For humandeclarative memories, cued memory reactivation during sleep seems to directly stabilizememories and enhance recall performance (Diekelmann et al., 2011).Different sleep stages have been proposed to be involved in the process of memoryconsolidation, yet little is known about the effectiveness of cued memory reactivation in differentsleep stages. Here we directly compared cued memory reactivation during SWS and sleepstage 2 (S2) in a within-subject design. Subjects learned a sound-word association memory taskin the evening. During subsequent sleep, we presented half of the sound cues during SWS andthe other half during S2, in counterbalanced order. We found that memory performance in thenext morning was significantly better when cues were presented during SWS than during S2.These findings suggest that targeting memory reactivation with external reminder cues is moreeffective during SWS than S2, speaking for a functional role of SWS for the consolidation ofdeclarative memories.