Antiinflammatory activity of structuraly related natural flavonoids

ALBERTO MARÍA R.; NIEVA MORENO M.I; ZAMPINI IRIS C.; ISLA MARÍA I.

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Arom¨¢ticas

On-line

Año: 2007 vol. 6 p. 308 - 309

The present study was conduced to investigate the effect of two types of bioactive flavonoids, structurally related, isolated from Z. punctata on cyclooxigenase-2 (COX-2) and cyclooxygenase-1 (COX-1). Chalcone was more active than flavone on COX-2. The cytoprotective and antioxidant activity demonstrated for both structurally related flavonoids may contribute to the anti-inflammatory effect. KEYWORDS: flavone, chalcone, COX-1, COX-2 KEYWORDS: flavone, chalcone, COX-1, COX-2