The involvement of allosteric effectors and post-translational modifications in the control of plant central carbon metabolism

HARTMAN MD; ROJAS BE; IGLESIAS AA; FIGUEROA CM

PLANT JOURNAL

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2023

0960-7412

Plant metabolism is finelyorchestrated to allow the occurrence of complementary and sometimes oppositemetabolic pathways. In part, this is achieved by the allosteric regulation ofenzymes, a cornerstone of plant research for many decades. The completion ofthe Arabidopsis genome and the development of the associated toolkits forArabidopsis research moved the focus of many researchers to other fields. Thisis reflected by the increasing number of high-throughput proteomic studies, mainlyfocussed on post-translational modifications. However, follow up “classical”biochemical studies to assess the functions and upstream signalling pathwaysresponsible for such modifications have been scarce. In this work, we reviewedthe basic concepts of allosteric regulation of enzymes involved in plant carbonmetabolism, comprising photosynthesis and photorespiration, starch and sucrosesynthesis, glycolysis and gluconeogenesis, the oxidative pentose phosphate pathway,and the tricarboxylic acid cycle. Additionally, we revisited the latest resultson the allosteric control of the enzymes involved in these pathways. Toconclude, we elaborated on the current methods for studying protein-metaboliteinteractions, which we consider will become crucial for discoveries in thefuture.