Photolablie, immobilizable caged compounds: Uncovering a new species of ligand-releasing complexes

BENJAMIN SCHWATZ; ROLANDO CARABALLO; LUIS M. BARALDO

San Diego, CA

Congreso; 243rd National Spring Meeting of the American-Chemical-Society (ACS); 2012

ACS

Ruthenium complexes containing 2,2?-bipyridine (bpy) have proven to be very effective in the photoliberaration of molecules of biological interest (caged compounds) due to the very well established photolabile nature of some of its compounds (1). For example the complex [Ru(bpy)2py2]2+ (py = pyridine) has a quantum yield of 0.26 for the photorealease of a pyridine. The ligand 1,10-phenantroline-5,6-dione (phen-dione) is an attractive alternative to the 2,2?-bipyridine, as not only it is rigid and may share some of its photophysical properties, but also can be immobilized on the surface of transition metal oxides, like TiO2 (2). In this presentation we report the synthesis and characterization of the complex [Ru(phen-dione)2py2]2+ including its photophysical properties. Substitution of the pyridine by other molecules can result in a family of caged compounds able to release molecules from different surfaces. 1. (1) ?A New Strategy for Neurochemical Photodelivery: Metal-Ligand Heterolytic Cleavage? Zayat, L.; Calero, C.; Alborés, P.; Baraldo, L. M.; Etchenique R.; J. Am. Chem. Soc., 2003, 125; 882-883. 2. ?Structural effects of self-assembled Prussian blue confined in highly organized mesoporous TiO2 on the electrocatalytic properties towards H2O2 detection?, Gaitán, M.; Gonçales, V. R.; Soler-Illia, G. J. A. A.; Baraldo, L. M.; Córdoba de Torresi, S. I.; Biosens. & Bioelect. 2010, 26, 890-893.