APPROACHES FOR ESTIMATING BURDEN OF PNEUMOCOCCAL AND ROTAVIRUS DISEASES: CONCEPTUAL FRAMEWORK AND SYSTEMATIC REVIEW

GARCIA MARTÍ, SEBASTIAN; ALCARAZ A; VALANZASCA, P; CIAPPONI, AGUSTÍN; BARDACH, ARIEL; SINHA A; AUGUSTOVSKI, F

Congreso; ISPOR 4th Latin America Conference 2013; 2013

ISPOR

OBJECTIVES: Country level estimation of disease burden promotes the understanding of the problem and can help prioritize the planning and implementation of programs, and thus foster the better use of scarce resources. Our aim was to review burden of disease (BoD) estimation methods and develop a guidance for conducting local disease burden exercises for pneumococcal and rotavirus diseases in Latin America and the Caribbe (LAC).  METHODS: We developed an algorithm to guide in a BoD study based on the availability of the different data sources and a systematic review of the different approaches used in the estimation of BoD pneumococcal and rotavirus disease studies worldwide. We followed the MOOSE guidelines for systematic reviews of observational studies, and the PRISMA statement for systematic reviews and meta-analyses. We searched studies published between January 1995 to September 2010 without language restriction on MEDLINE, EMBASE, LILACS, generic and academic Internet search and meta-search engines.  RESULTS: The algorithm developed include five approaches: based on end results; based on the end and intermediate results (using health services); based on incidence and end results; partial approach; and based on incidence. The systematic review retrieves 1728 articles. After pair assessment, we include 92 in title/abstract phase and finally 35 in full text phase for extraction. Single or multiple approaches based on incidence were the most used (57%), based on intermediate results are in the second place (53%) and based on final results are the least used (43%). 48% of the based on final results studies/substudies, 46% of those based on intermediate results, and 36% of those based on incidence were considered to be representative for the jurisdiction of interest. CONCLUSIONS: The present work describes a taxonomy of BoD estimation and provides guidance for LAC and other LMIC countries according to local data availability.