APPROACHES FOR ESTIMATING BURDEN OF PNEUMOCOCCAL AND ROTAVIRUS DISEASES: CONCEPTUAL FRAMEWORK AND SYSTEMATIC REVIEW

GARCIA MARTI S ; VALANZASCA P,; CIAPPONI A, ; BARDACH A,; SINHA A,; AUGUSTOVSKI F.

WHO TECHNICAL REPORT SERIES

WORLD HEALTH ORGANIZATION

Lugar: Ginebra; Año: 2013

0512-3054

Objectives: Country level estimation of disease burden promotes the understandingof the problem and can help prioritize the planning and implementation ofprograms, and thus foster the better use of scarce resources. Our aim was to reviewburden of disease (BoD) estimation methods and develop a guidance for conductinglocal disease burden exercises for pneumococcal and rotavirus diseases in LatinAmerica and the Caribbe (LAC). Methods: We developed an algorithm to guide ina BoD study based on the availability of the different data sources and a systematicreview of the different approaches used in the estimation of BoD pneumococcal androtavirus disease studies worldwide. We followed the MOOSE guidelines for systematicreviews of observational studies, and the PRISMA statement for systematicreviews and meta-analyses. We searched studies published between January 1995 toSeptember 2010 without language restriction on MEDLINE, EMBASE, LILACS, genericand academic Internet search and meta-search engines. Results: The algorithmdeveloped include five approaches: based on end results; based on the end andintermediate results (using health services); based on incidence and end results;partial approach; and based on incidence. The systematic review retrieves 1728articles. After pair assessment, we include 92 in title/abstract phase and finally 35in full text phase for extraction. Single or multiple approaches based on incidencewere the most used (57%), based on intermediate results are in the second place(53%) and based on final results are the least used (43%). 48% of the based on finalresults studies/substudies, 46% of those based on intermediate results, and 36%of those based on incidence were considered to be representative for the jurisdictionof interest. Conclusions: The present work describes a taxonomy of BoDestimation and provides guidance for LAC and other LMIC countries according tolocal data availability.