Burden of Heart Failure in Latin America: A Systematic Review and Meta-analysis.

CIAPPONI A,; ALCARAZ A, ; CALDERÓN M,; MATTA MG,; CHAPARRO M,; SOTO N,; BARDACH A

VALUE IN HEALTH

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2016

1098-3015

Objectives: Heart failure (HF) is a common clinical syndrome representing theend-stage of several cardiac diseases. Our objective was to estimate the burden ofheart failure in Latin America. Methods: A systematic review and meta-analysiswas performed. We searched in MEDLINE, EMBASE, LILACS, and CENTRAL fromJanuary 1994 to June 2014. We included non-comparative data from experimentaland observational studies. No language restriction was imposed. We included studieswith samples of at least 50 participants of 18 years of age or older with HF. Theoutcomes analyzed were incidence, prevalence, hospitalization rates and case fatalityratios of HF at different time points, length of stay and mortality. Results: Thesearch retrieved 4792 references of which 143 studies were finally included. Most were conducted in South America (92%), particularly in Brazil (64%). The mean agewas 60 ± 9 years and the mean ejection fraction was 36 ± 9%. Most studies evaluatedmore than one etiology (79%) but the etiology more studies exclusively wasChagas disease (13%). The incidence of HF ranged from 199 to 557 cases per 100,000person-years and the pooled prevalence was 1%, being higher in older populations.Hospitalization rates in patients with HF ranged from 28 to 31% at different timepoints, and the median length of stay was 7.0 days. In-hospital mortality was 11.7%,being higher in patients with worse ejection fraction, with ischemic and with Chagasdisease. Mortality at one year was 24.52% (95%CI 19.42 to 30.02). Conclusions:This SR of HF in Latin America, could help decision-makers to