Recent advances in four- and five- way excitation-emission luminescence-based data acquisition and modeling for analytical applications

A MUÑOZ DE LA PEÑA; ALCARÁZ, MIRTA R.; O MAÑAGO; GOICOECHEA H C

Menorca

Congreso; X Colloquium Chemiometricum Mediterraneum; 2019

The growing interest in multi-way analysis is reflected in the large number of reports that are found in the literature.Numerous analytical applications based on multivariate calibration have been developed capitalizing on theadvantages offered by the higher-order modeling. Nonetheless, third- and fourth-order analytical applications arestill scarce despite all the benefits that have been demonstrated for third- and fourth-order calibration analysis[1]. This work shows a report focused on excitation ? emission luminescence matrices generation, employingdifferent variables as the third data mode (time retention in chromatography, pH gradient, luminescence lifetime,kinetics, or other chemical treatments). The synergistic effect of combining excitation-emission luminescence datawith higher-order calibration has been widely exploited in different fields (environmental, biological, foods). Fullycapitalizing on the second-order advantage, it had been possible to develop appealing analytical applications inspite of the data complexity. The experimental works reported up to date will be presented and discussed in orderto illustrate concepts. As an example, Figure 1 shows original fluorescence images, acquired with a CCD-basedfluorescence detector, in function of the chromatographic retention time, and subjected to four-way PARAFACdecomposition [2]. The existence of third-order advantages, whose has been supported with experimentalevidences by a number of authors, will be reviewed. The main advantages that have been supported withexperimental evidences are 1) the possibility of decomposing a data array for each sample and independent ofother samples, 2) the enhancement of the sensitivity and selectivity, by incorporation of additional information ofthe sample through a third instrumental mode and 3) the possibility to tackle collinearity problems arisen from theintroduction of an extra mode. However, more works on the development on the fundamental theories and newapplications are needed to fully understand the properties of third? and fourth- order calibration.