Chemometric strategies for enhancing the chromatographic methodologies with second-order data analysis of compounds when peaks are overlappe

GOICOECHEA, HÉCTOR C; CULZONI M J; GIL GARCÍA, MARÍA; MARTINEZ GALERA, MARIA

TALANTA

ELSEVIER SCIENCE BV

Año: 2011 vol. 83 p. 1098 - 1107

0039-9140

This overview covers the different chemometric strategies linked to chromatographic methodologiesthat have been used and presented in the recent literature to cope with problems related to incompleteseparation, the presence of unexpected components in the sample, matrix effect and changes in theanalytical signal due to pre-treatment of sample.Among the different chemometric strategies it focuses on pre-treatment of data to correct backgroundand time shift of chromatographic peaks and the use of second-order algorithms to cope with overlappingpeaks from analytes or from analytes and interferences in liquid chromatography coupled to diode array,fast-scanning fluorescence spectroscopy and mass spectrometry detectors. Finally the review presentsthe strategies used to deal with changes in the analytical response as result of matrix effect in liquidand gas chromatography, as well as the use of standardization strategies to correct modifications in theanalytical signal as a consequence of sample pre-treatment in liquid chromatography.