INVESTIGADORES
ANGEL Sergio Oscar
artículos
Título:
TOXOPLASMA GONDII HSP90: POTENTIAL ROLES IN ESSENTIAL CELLULAR PROCESSES OF THE PARASITE
Autor/es:
ANGEL SO; FIGUERAS MJ; ALOMAR L; ECHEVERRIA PC; DENG BIN
Revista:
PARASITOLOGY
Editorial:
CAMBRIDGE UNIV PRESS
Referencias:
Lugar: Cambridge; Año: 2014
ISSN:
0031-1820
Resumen:
HSP90
is a widely distributed and highly conserved molecular chaperone that is
ubiquitously expressed throughout nature, being one of the most abundant
proteins within non-stressed cells. This chaperone is up-regulated following
stressful events and has been involved in many cellular processes. In T. gondii, HSP90 could be linked with
many essential processes of the parasite such as host cell invasion, replication
and tachyzoite-bradyzoite interconversion. A Protein-Protein Interaction (PPI)
network approach of TgHSP90 has allowed inferring how these processes may be
altered. In addition, data mining of T. gondii
phosphoproteome and acetylome has allowed the generation of the
phosphorylation and acetylation map of TgHSP90. This review focuses on the
potential roles of TgHSP90 in parasite?s biology and the analysis of
experimental data in comparison with its counterparts in yeast and humans.