GARCIA adolfo Martin
congresos y reuniones científicas
Deficits in emotion recognition monitoring in dementia patients
GARCÍA-CORDERO, INDIRA; MIGEOT, JOAQUÍN; AQUINO, ALEXIA; FITTIPALDI, SOL; DÍAZ-RIVERA, MARIANO; SEDEÑO, LUCAS; GARCÍA, ADOLFO M.; IBÁÑEZ, AGUSTÍN
Conferencia; Alzheimer?s Association International Conference; 2020
Background: The capacity to ascertain other people?s emotional states is crucial for establishing and maintaining social interactions. In particular, accurate recognition of facial expressions and beliefs about whether we trust what a face transmits are fundamental for guiding and adjusting this social behavior. Yet, although emotion recognition impairments are well documented in neurodegenerative diseases, the role of monitoring skills in this domain remains poorly understood in the field of dementia. Method: We recruited patients with behavioral variant frontotemporal dementia (bvFTD, n = 18), Alzheimer?s disease (AD, n = 27), and demographically-matched controls (n = 34). Participants performed a classic test of facial expression recognition and, after each trial, they provided a confidence judgment about their performance. A monitoring index was calculated considering both performance on each emotion type and associated confidence ratings (with higher values of the index indicating worse monitoring). Then, whole-brain grey matter volume was analyzed via voxel-based morphometry (VBM) to track possible associations with the monitoring index.Results: Compared to controls, both groups of patients exhibited difficulties in monitoring negative and positive emotions. In particular, monitoring of disgust and happiness was specifically impaired in bvFTD and monitoring of sadness and neutral faces was altered in AD. VBM results showed that, in bvFTD patients, reduced grey matter volume in subcortical regions (thalamus, amygdala, basal ganglia) was associated with higher monitoring scores for negative emotions, whereas atrophy of fronto-parietal and limbic regions was related with higher monitoring scores for positive emotions. On the other hand, in AD patients, reduced grey matter volume in the inferior frontal gyrus was related with higher monitoring scores for positive emotions, there being no associations for negative emotions.Conclusion: These results indicate that dementia patients present emotion recognition monitoring impairments and that these deficits are associated with disruptions of cortical and subcortical executive regions as well as limbic circuits. The monitoring impairments presented in bvFTD and AD could be related with the changes in social cognition, personality, and behavior that these patients presented in daily life. Therefore, these preliminary findings could contribute to a better understanding of relevant brain functions, and specifically, of emotion recognition monitoring processes.