INVESTIGADORES
GARCIA adolfo Martin
congresos y reuniones científicas
Título:
Anatomical and functional correlations of interoceptive dimensions in neurodegeneration and stroke
Autor/es:
GARCÍA-CORDERO, INDIRA; SEDEÑO, LUCAS; DE LA FUENTE, LAURA; FORNO, GONZALO; FERRARI, JESSICA; RODRIGUEZ, CLARA; TORRALVA, TERESA; BAEZ, SANDRA; MOGUILNER, SEBASTIÁN; YORIS, ADRIÁN; ESTEVES, SOL; MELLONI, MARGHERITA; SALAMONE, PAULA; MANES, FACUNDO; GARCÍA, ADOLFO M.; IBÁÑEZ, AGUSTÍN
Lugar:
Buenos Aires
Reunión:
Encuentro; 20th Annual Meeting of the Association for the Scientific Study of Consciousness; 2016
Institución organizadora:
Association for the Scientific Study of Consciousness
Resumen:
Interoception, the ability to sense autonomic changes via viscero-cortical pathways, encompasses multiple dimensions and relies on widespread neural hubs. Methods: we assessed cardiac interoceptive accuracy, learning, and awareness through the heartbeat detection task (HBD) in healthy subjects and behavioral variant frontotemporal dementia (bvFTD), Alzheimer?s disease (AD), and fronto-insular stroke patients. Neural correlates of the three dimensions were examined through structural and functional resting-state imaging and online measurements of the heart-evoked potential (HEP). Results: The three patient groups presented deficits in interoceptive accuracy, associated to insular affectation, connectivity alterations, and abnormal HEP modulations. Interoceptive learning was differentially impaired in AD patients, suggesting a key role of memory skill. Interoceptive awareness results showed that bvFTD and AD patients overestimated their performance, associated to abnormal frontal networks engaged in to metacognitive processes. Discussion: Our findings demonstrate that damage in specific hubs in the broad fronto-temporo-insular networks produce alterations of body sensing, offering new theoretical insights into neuroanatomical foundations of interoceptive dimensions. [Work partially supported by CONICET, CONICYT/FONDECYT Regular (1130920), COLCIENCIAS (1115-545-31374 and 1115-569-33858), FONCyT-PICT 2012-0412, FONCyT-PICT 2012-1309, FONDAP 15150012, and INECO Foundation.]