FOXP3 EXERTS PROTUMORAL INTRINSIC EFFECTS IN GLIOBLASTOMA CELLS

GARCIA FALLIT, MATÍAS; JORGE A. PEÑA AGUDELO; MELANIE PÉREZ KUPER; NAZARENO GONZALEZ; NOELIA CASERES; JUAN JOSE LASARTE; ADRIANA SEILICOVICH; FLAVIA ZANETTI; GUILLERMO VIDELA RICHARDSON; MARIANELA CANDOLFI

Mar Del Plata

Otro; Reunión Anual de Sociedades de Biociencia (SAIC, SAB, AAFE, AACyTAL); 2023

Glioblastomas (GBM) are the most frequent and aggressive primary malignant brain tumors in adults. Although the survival of thesepatients is 12-18 months, their treatment remained unchanged forthe last 20 years. Foxp3, a transcription factor required for the development and immunosuppressive activity of regulatory T cells hasalso been detected in several types of tumoral cells. However, thetumor intrinsic role of Foxp3 is poorly understood. We have previously shown that Foxp3 exerts intrinsic pro-tumoral effects in breastcancer cells and that administration of a cell-penetrating Foxp3 inhibitory peptide (P60) improves the efficacy of antitumor vaccinesand exerts direct antitumor effects, inhibiting the progression ofexperimental breast cancer. Here we aimed to assess the intrinsiceffects of Foxp3 in GBM cells. Our meta-analysis of transcriptomicdata from GBM biopsies indicated that Foxp3 is expressed in thesetumors and it is significantly associated with worse prognosis inGBM patients. We found expression of Foxp3 in murine and humanGBM cell lines and patient-derived cultures, which was upregulatedby chemotherapy (p