TARGETING FOXP3 TUMOR INTRINSIC EFFECTS USING ADENOVIRAL VECTORS IN EXPERIMENTAL BREAST CANCER

ALEJANDRO J. NICOLA CANDIA; MATÍAS GRACÍA FALLIT; JORGE A. PEÑA AGUDELO; MELANIE PÉREZ KÜPER; NAZARENO GONZALEZ; NOELIA CASARES; ADRIANA SEILICOVICH; JUAN JOSÉ LASARTE; FLAVIA A. ZANETTI; MARIANELA CANDOLFI

Mar Del Plata

Otro; Reunion anual de sociedades de biociencia; 2023

Regulatory T cell master transcription factor, Forkhead box P3 (Foxp3) has been detected in cancer cells, but its role in breast tumor pathogenesis remains controversial. Here we assessed Foxp3 tumor intrinsic effects in experimental humen breast cancer cells using a Foxp3 binder peptide (P60) that impairs Foxp3 nuclear translocation. Foxp3 expression varies among triple negative breast cancer (TNBC) cells, being higher in MDA-MB-468 (60%), than in MDA- MB-231 (25%). Nevertheless, Cisplatin upregulated the Foxp3 expression in MDA-MB-231 (43%; p