BLANK viviana Claudia
Antiproliferative activity of various flavonoids and related compounds. Additive effect of interferon-alpha2b
BLANK VIVIANA; POLI CECILIA; MARDER MARIEL; ROGUIN LEONOR
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
PERGAMON-ELSEVIER SCIENCE LTD
Año: 2004 vol. 14 p. 133 - 136
The antiproliferative activity of several natural and synthetic ﬂavonoids and some related compounds was evaluated in vitro against a cell line derived from a human cervical carcinoma (WISH cells). According to their activities, the most potent derivatives were 20 -nitroﬂavone (14), 20 ,6-dinitroﬂavone (15) and the n-buthyl ester of caﬀeic acid (29). When these compounds were tested in the presence of recombinant human interferon-a2b (rhIFN-a2b), a cytokine exhibiting an antimitogenic action on WISH cells, an additive eﬀect on cell growth inhibition was observed. Time course studies of the antiproliferative action exerted by the active derivatives or the rhIFN-a2b suggested that these compounds induced cell death.