Cross frequency coupling analysis of local field potentials recorded from rat hippocampal and parahippocampal regions during behavioral tasks

JAVIER VELEZ; EUGENIO URDAPILLETA; OSVALDO VELARDE; GERMÁN MATO; DAMIÁN DELLAVALE

Buenos Aires

Congreso; 2nd Congress of the Federation of Latin-American and Caribbean Societies for Neuroscience; 2023

Federation of Latin-American and Caribbean Societies for Neuroscience

The cross-frequency coupling (CFC) characterizes the correlation between properties (phase/amplitude) of a low-frequency band with those of a high-frequency band within or across time series.The nonlinear interaction between different frequency bands in the form of CFC has been observed not only within functionally specialized brain areas, but also between functionally distinct neuronal subpopulations. Several studies have suggested that cross-location CFC is important because of its potential role in regulating inter-area communication. Evidence has shown that hippocampal-striatal phase-amplitude CFC is dynamically modulated alongside behavioral task demands in rat, and hippocampal theta phase can also modulate neocortical gamma power.In this work we investigate the CFC phenomenon in local field potentials (LFP) recorded from rat hippocampal and parahippocampal regions during several behavioral tasks. The LFP signals were analyzed using a CFC algorithm which computes the modulation index for estimating phase-amplitude coupling based on a normalized entropy measure. Surrogate analysis was performed to assess the statistical significance of the modulation observed. Moreover, we examine the CFC phenomenon as a function of the time lag between frequency bands in connection with the information flow in the hippocampal network.