RGD-FUNCTIONALIZATION OF ANODIZED ZIRCONIUM AS A POTENTIAL STRATEGY FOR BIOMEDICAL APPLICATION: AN IN VITRO STUDY

TANO DE LA HOZ M.F.; GOMEZ SANCHEZ A.; MARISCOTTI, V.; PROCACCINI, R.; MICHELETTI, M.; BARBINI, L.; KATUNAR M.R.; CERÉ, S.

Congreso; 11° Latin American Congress of Artificial Organs and Biomaterials; 2021

Zirconium (Zr) and its alloys has been proposed as apromising material for use in biomedical implants [1].Anodization represents an efficient route for surfacemodification that allows the surface design in the nano andmicro scales fundamental for the improving implantsperformance. In previous studies, anodic growth of ZrO2surface films in phosphoric acid resulted beneficial for implantosseointegration [1-3]. In the last decade, numerous studieshave focused on achieving greater control over the biologicalinteractions between the implant and the surrounding tissueby immobilizing biomolecules that could interact with theextracellular matrix [4]. In the present study, the effect offunctionalization of anodized Zr with RGD peptides (arginineglycine-aspartic acid sequences) on cell behavior as afeasible approach to stimulate its bioactivity is presented.