Evaluation of annealed titanium oxide nanotubes on titanium. From surface characterization to in vivo assays

GOMEZ SANCHEZ A.; KATUNAR M.R.; PASTORE JI; TANO DE LA HOZ M.F.; CERE S.

Journal of Biomedical Materials Research - Part A

Wiley Periodicals, Inc.

Año: 2020

1549-3296

The entire route from anodic oxidation and surface characterization, including in vitroexperiments and finally in vivo osseointegration assays were performed with the aim toevaluate nanotubular and crystalline annealed titanium oxides as a suitable surface for grade 2titanium permanent implants.Polished titanium (T0) was compared with anodized surfaces obtained in acidic media withfluoride, leading to an ordered nanotubular structure of titanium oxide on the metal surface,characterized by tube diameter of 89 ± 24 nm (Tnts). Samples were thermally treated in air(TntsTT) to increase the anatase crystalline phase on nanotubes, with minor alteration of thestructure. Corrosion tests were performed to evaluate the electrochemical response after 1, 14and 28 days of immersion in simulated body fluid (SBF). Based on the in vitro results, heattreated titanium nanotubes (TntsTT) were selected as a promissory candidate to continue withthe osseointegration in vivo assays. The in vivo results showed no major improvement in theosseointegration process when compared with untreated Ti after 30 days of implantation andthere also was a lower increase in the development of new osseous tissue.