Maternal ancestry and hematological cancer risk: case-control study in an Argentinean population

CERLIANI MARÍA BELÉN; MAYORDOMO ANDREA CONSTANZA; SANCHEZ DOVA ANACLARA; SOAREZ JULIETA; FUHR JOSEFINA; PIÑERO TAMARA; CAJAL ANDREA ROMINA; JAUK VITALI FEDERICO; GARCÍA RIVELLO HERNÁN; VACCARO CARLOS; RICHARD SILVINA; BRAVI CLAUDIO M.; PAVICIC WALTER

PERSONALIZED MEDICINE

FUTURE MEDICINE LTD

Lugar: Londres; Año: 2021 vol. 13 p. 269 - 281

1741-0541

BackgroundNeoplastic hematological malignancies (HMs) incidence and mortality rates vary from one country to another, even in Argentina this occurs across the country. The Argentinean population genetic background presents an interethnic admixture whose proportions differ within regions. Our study?s aim was to evaluate the role of ancestry in HMs risk in a population from Central Argentina.ResultsWe analyzed the entire mitochondrial control region to estimate the maternally inherited ancestry and haplogroups in 125 cases with HMs and 310 controls. Further, 124 cancer patients from a private hospital, were also assessed. A statistically significant decreased risk for HMs was associated with the Native American haplogroup B2 (OR=0.49, 95% CI 0.25-0.92, p=0.02). On the other hand, the sub-Saharan African parahaplogroup L was linked with higher susceptibility for disease (OR=3.10, 95% CI 1.04-9.31, p=0.043). Although the mean ancestral proportions in the total studied population was as published (61.7% Native American, 34.6% European, and 3.7% African), an unequal continental ancestry distribution was observed when comparing patients from public versus private hospitals.ConclusionsWe confirmed the tri-hybrid nature of the Argentinean population, with proportions varying within the country. Our finding supports the notion that linked haplogroup is population- and cancer-specific. The presence of a region-specific genetic diversity across Argentina needs to be considered in medical association studies carried out in our population.