The Simons Genome Diversity Project: 300 genomes from 142 diverse populations

SWAPAN MALLICK; HENG LI; MARK LIPSON; IAIN MATHIESON; MELISSA GYMREK; FERNANDO RACIMO; MENGYAO ZHAO; NIRU CHENNAGIRI; SUSANNE NORDENFELT; ARTI TANDON; PONTUS SKOGLUND; IOSIF LAZARIDIS; SRIRAM SANKARARAMAN; QIAOMEI FU; NADIN ROHLAND; GABRIEL RENAUD; YANIV ERLICH; THOMAS WILLEMS; CARLA GALLO; JEFFREY P. SPENCE; YUN S. SONG; GIOVANNI POLETTI; FRANCOIS BALLOUX; GEORGE VAN DRIEM; PETER DE KNIJFF; IRENE GALLEGO ROMERO; AASHISH R. JHA; DORON M. BEHAR; CLAUDIO M. BRAVI; CRISTIAN CAPELLI; TOR HERVIG; ANDRES MORENO-ESTRADA; OLGA L. POSUKH; ELENA BALANOVSKA; OLEG BALANOVSKY; HOVHANNES SAHAKYAN; DRAGA TONCHEVA; LEVON YEPISKOPOSYAN; CHRIS TYLER-SMITH; YALI XUE; M. SYAFIQ ABDULLAH; ANDRES RUIZ-LINARES; CYNTHIA M. BEALL; ANNA DI RIENZO; CHOONGWON JEONG; ELENA B. STARIKOVSKAYA; ENE METSPALU; JÜRI PARIK; RICHARD VILLEMS; ANTTI SAJANTILA; GEORGE STAMATOYANNOPOULOS; RITA KHUSAINOVA; ELZA KHUSNUTDINOVA; SERGEY LITVINOV; DAVID COMAS; MICHAEL HAMMER; TOOMAS KIVISILD; WILLIAM KLITZ; MICHAEL BAMSHAD; LYNN B. JORDE; SARAH A. TISHKOFF

NATURE

NATURE PUBLISHING GROUP

Lugar: Londres; Año: 2016 vol. 538 p. 201 - 206

0028-0836

We report the Simons Genome Diversity Project (SGDP) dataset: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergence. We show that the ancestors of some pairs of present-day human populations were substantially separated by 100,000 years ago, well before the archaeologically attested onset of behavioral modernity. We also demonstrate that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that in other non-Africans.