Native American mitochondrial lineages in admixed populations from Chile: detecting recent migrations during post-Columbian times using geographically restricted lineages

PATRICIO PEZO; MICHAEL ORELLANA-SOTO; CONSTANZA DE LA FUENTE,; XIMENA LEIVA; LUISA HERRERA; SANDRA FLORES-ALVARADO; JACQUELINE GALIMANY; MICHELLE DE SAINT PIERRE; CLAUDIO M. BRAVI; MAURICIO MORAGA

American Journal of Biological Anthropology

Wiley

Lugar: NY; Año: 2022 vol. 178 p. 504 - 512

Objectives: To analyze the mitochondrial diversity in three admixed populations and evaluate the historical migration effect of native southern population to Santiago (capital of Chile). The intensity of migration was quantified using three mitochondrial lineages restricted to South-Central native groups.Methods: D-loop sequences were genotyped in 550 unrelated individuals from San Felipe-Los Andes (n=108), Santiago (n=217) and Concepción (n=225). Sequence processing, alignment and haplogroup inference was carried out, and different genetic structure analyses were performed for haplogroup frequencies and D-loop sequences. Results: The Native lineages B2i2, C1b13 and D1g were the most frequent haplogroups in our sample, especially in Santiago (71,8%). Despite the distance, this city showed a higher genetic affinity with southern populations, including Concepción ( ~500km distant) and native groups, rather than with those from San Felipe-Los Andes (