INVESTIGADORES
POSTEMSKY Pablo Daniel
congresos y reuniones científicas
Título:
ANTITUMORAL EFFECTS OF PLEUROTUS OSTREATUS I-FRACTION IN BREAST CANCER
Autor/es:
RAMBURGER, R; FERRONATO, M.J; GUEVARA, J.A; CUESTAS, J.M.; POSTEMSKY, P.D.; CURINO, A.C.; FACCHINETTI, M.M.; ALONSO, E.N.
Lugar:
Mar del Plata
Reunión:
Congreso; Congreso SAIC; 2019
Institución organizadora:
SAIC
Resumen:
Mushrooms are considered as "small pharmaceutical factories" producinghundreds of bioactive compounds, many of which have shown to exertantitumoral activity in different types of cancer. Argentina has a high mushroomsdiversity and important scientific-technological development applied to itscultivation. However, the antitumoral phytotherapeutic potential of ediblemushrooms cultivated in our country has not yet been considered. In this context,the purpose of the current study is to determine the antitumoral activity in breastcancer of Pleurotus ostreatus I-Fraction, an extract of water-solublepolysaccharides obtained from fruiting body, initially evaluating its potentialimmuno-independent antitumoral activity. To achieve the proposed objective, weemployed a murine mammary adenocarcinoma 4T1 cells line and performed cellviability assays by colorimetric assay with crystal violet, cell cycle analysis by flowcytometry, and wound healing assay. We found that P. Ostreatus I-Fraction atconcentration from 2.5 mg/mL and ranging from 1,0 to 2,5 mg/mL decreased theviability of 4T1 cells in a concentration-dependent manner, at 24 hours and 48hours respectively (p