Chitosan‐Based Formulations Intended as Protective Spray for Mask Surfaces in Prevention of Coronavirus Dissemination

AYALA?PEÑA, VICTORIA BELEN; MARTIN, MARÍA JULIA; FAVATELA, FLORENCIA; OTAROLA, JESSICA; MORÁN, PEDRO; VENTURA, MARÍA; GENTILI, CLAUDIA; SALCEDO, MARÍA FLORENCIA; MANSILLA, ANDREA; PÉREZ, SANDRA; DOLCINI, GUILLERMINA; ALVAREZ, VERA; LASSALLE, VERÓNICA

ChemistrySelect

wiley

Lugar: New York; Año: 2022 vol. 7

2365-6549

The extraordinary occurrence of COVID-19 by the fast expansionof viral infections has propelled particular interest indeveloping novel antiviral and virucidal agents to guaranteepersonal security. The main objective of this work is to proposenovel formulations able to optimize the use of personalprotection elements. In recent years, chitosan (CH) hasattracted attention for being an interesting multifunctional,biodegradable, non-antigenic, non-toxic, and biocompatiblenatural polymer with antimicrobial properties. In this work,formulations based on a CH matrix containing silver, andCopper based nanoparticles have been developed. The noveltyof this proposal is that almost liquid formulations have beenreached, possessing verified properties to inhibit evolved virussuch as herpes simplex type 1 (HSV-1) and bovine betacoronavirus(BCoV), the latter belonging to the same family of the wellknownthe well-known SARS-CoV-2. Besides antibacterialbioactivity; as well as the ability of these formulations to beeasily sprayed on various surfaces, including conventional facemasks, have been verified and discussed. The results presentedin this contribution provide strong evidence on CH films as anideal biosafe surface-protective for several daily used materialsincluding the conventional face masks.