Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function?

RUKAVINA MIKUSIC, NATALIA L.; SILVA, MAURO G.; PINEDA, ANGÉLICA M.; GIRONACCI, MARIELA M.

Frontiers in Pharmacology

Front Pharmacol

Año: 2020 vol. 11

G-protein?coupled receptors (GPCRs) are targets for around one third of currentlyapproved and clinical prescribed drugs and represent the largest and most structurallydiverse family of transmembrane signaling proteins, with almost 1000 members identifiedin the human genome. Upon agonist stimulation, GPCRs are internalized and traffickedinside the cell: they may be targeted to different organelles, recycled back to the plasmamembrane or be degraded. Once inside the cell, the receptors may initiate other signalingpathways leading to different biological responses. GPCRs? biological function may alsobe influenced by interaction with other receptors. Thus, the ultimate cellular response maydepend not only on the activation of the receptor from the cell membrane, but also fromreceptor trafficking and/or the interaction with other receptors. This review is focused onangiotensin receptors and how their biological function is influenced by trafficking andinteraction with others receptors.