Automatic landmarking identifies new loci associated with face morphology and implicates Neanderthal introgression in human nasal shape

LI, QING; CHEN, JIEYI; FAUX, PIERRE; DELGADO, MIGUEL EDUARDO; BONFANTE, BETTY; FUENTES-GUAJARDO, MACARENA; MENDOZA-REVILLA, JAVIER; CHACÓN-DUQUE, J. CAMILO; HURTADO, MALENA; VILLEGAS, VALERIA; GRANJA, VANESSA; JARAMILLO, CLAUDIA; ARIAS, WILLIAM; BARQUERA, RODRIGO; EVERARDO-MARTÍNEZ, PAOLA; SÁNCHEZ-QUINTO, MIRSHA; GÓMEZ-VALDÉS, JORGE; VILLAMIL-RAMÍREZ, HUGO; SILVA DE CERQUEIRA, CAIO C.; HÜNEMEIER, TÁBITA; RAMALLO, VIRGINIA; WU, SIJIE; DU, SIYUAN; GIARDINA, ANDREA; PARIA, SOUMYA SUBHRA; KHOKAN, MAHFUZUR RAHMAN; GONZALEZ-JOSÉ, ROLANDO; SCHÜLER-FACCINI, LAVINIA; BORTOLINI, MARIA-CÁTIRA; ACUÑA-ALONZO, VICTOR; CANIZALES-QUINTEROS, SAMUEL; GALLO, CARLA; POLETTI, GIOVANNI; ROJAS, WINSTON; ROTHHAMMER, FRANCISCO; NAVARRO, NICOLAS; WANG, SIJIA; ADHIKARI, KAUSTUBH; RUIZ-LINARES, ANDRÉS

Communications Biology

Nature Research

Año: 2023 vol. 6

We report a genome-wide association study of facial features in >6000 Latin Americans based on automatic landmarking of 2D portraits and testing for association with inter-landmark distances. We detected significant associations (P-value