Self-assembled vesicles from electrospun amphiphilic fibers

SANCHEZ CERVIÑO, M. CELINA; RIVERO GUADALUPE

Iasi

Congreso; 32 International Congress of ?Apollonia? University from Iași; 2022

Vesicles are supramolecular spherical structures with great potential as nanocarriers in drug delivery systems. While controlling the self-assembly vesicles formation processes used to be expensive and complex; we explored electrospun amphiphilic fibers as templates for the in situ formation of vesicles when sub-micrometric fibers are dissolved in water. Nanofabrication methods as electrospinning, pre-confines the hydrophilic and phospholipid components, thus tuning the molecular arrangement when fibers are dissolved. In this work, different fibers composed of polyvinylpyrrolidone K60 and soybean lecithin were electrospun in order to manipulate the molecular self-assembly for the synthesis of vesicles. The main objective is to correlate the characteristics of the formed vesicles with the morphological and compositional features of the precursor fibers and the involved processing parameters. Results showed that smaller vesicles were obtained from narrower fiber distributions. As the porosity of the sub-micrometric fibrous membranes increased, the polydispersity index of the vesicles was markedly decreased.