Neutrophilic Inflammation and Diseases: Pathophysiology, Biomarkers and Therapeutic Targets

SANDRA E. GOMEZ MEJIBA; DARIO C. RAMIREZ

ELIVA PRESS

Año: 2020 p. 178

978-1952751387

Endogenous (in the blood) or exogenous stressors can irritate tissues increasing adhesion and activation of neutrophils. This process is known as neutrophilic inflammation and includes activation of neutrophils. This activation of neutrophils includes the activation of myeloperoxidase (MPO), NADPH oxide-reductase (NOX-2) and inducible nitric oxide synthase (iNOS) with generation of harmful neutrophil extracellular traps (NETs), and a broad range of reactive biochemical species. Oxidative modification can change the structure and function of macromolecules leading to tissue damage and diseases. NETs, MPO, NOX-2 and iNOS, as well as proteases and oxidized macromolecules are useful biomarkers of diseases as well as potential therapeutic targets. This book is focused in the latest information about the role of neutrophilic inflammation in the pathogenesis of acute and chronic diseases, as well as novel biomarkers and therapeutic targets. In silico, in vitro, ex-vivo and in vivo experimental studies are comprehensively discussed in light of the most current information in this field.