Diet-induced pulmonary inflammation and incipient fibrosis: a possible role of neutrophilic inflammation

DELLA VEDOVA, MC; SOLER GARCIA, MF; MUNOZ MD; FORNES, M.W; GOMEZ MEJIBA, SE; GOMEZ, NN; RAMIREZ, DC

INFLAMMATION

SPRINGER/PLENUM PUBLISHERS

Lugar: New York; Año: 2019

0360-3997

Chicken-fat and fructose are added into food-processing to reduce costs and enhance acceptability; however, these additives turn food into unhealthy and hypercaloric meals. We hypothesize that chronic feeding with chicken-fat and fructose, together or by separate, can cause pulmonary redox and inflammatory changes. These changes are particularly related to neutrophils and myeloperoxidase, with consequent changes in the organ histo-physiology. To test this hypothesis we fed mice for 16 weeks with either, control food (low-fat diet, LFD) or control food supplemented with 22% chicken-fat, and with or without 10% fructose in the drinking water. At the end of the feeding regimen, we measured redox and inflammatory changes in the lung with particular emphasis on neutrophil accumulation/activation and molecular-histological markers of fibrosis. Our results suggest that a diet supplemented with chicken-fat and fructose causes additive effects on pulmonary oxidative stress, inflammation, and a pro-fibrotic status. Neutrophilic inflammation may play a critical role in pulmonary pathology associated with metabolic syndrome.