Reduced blood Nrf-2 mRNA in local overweight boys at risk of metabolic complications: A study in San Luis City, San Luis, Argentina

SANTILLAN, LUCAS DAMIAN; MOYANO, MARTA; FRAU, MARTIN ; FLORES, OSVALDO ; SIEWERT, SUSANA ; ZIRULNICK, FANNY ; DARIO C. RAMIREZ; GIMENEZ, MARIA SOFIA

METABOLIC SYNDROME AND RELATED DISORDERS

MARY ANN LIEBERT INC

Lugar: New York; Año: 2013

1540-4196

Background: Childhood overweight is a matter of public health concern because its long-term impact on adulthood health. NF­E2-related factor 2 (Nrf-2) regulates the antioxidant/lipogenic response to a sustained positive energy balance that prevails during weight gain. Herein, we aimed at studying a possible link between overweight and Nrf-2-dependent antioxidant/lipogenic response in a local population of boys at risk of metabolic complications. Methods: We measured clinical and biochemical parameters related to lipid metabolism, oxidative stress and metabolic syndrome in a population of overweight boys (OW, BMI percentile ≥ 85th and