Taq1B CETP Polymorphism and cardiovascular risk in an endogamous population of diabetic men: A study in Santa Rosa del Conlara, San Luis, Argentina

SIEWERT, SUSANA; GONZALEZ, IRMA; SERGIO FILIPUZZI; DARIO C. RAMIREZ; MARTA SUSANA OJEDA

Journal of Diabetes Mellitus

Scientific Research - Script

Año: 2015

2160-5831

Objectives: Type 2 diabetes mellitus (T2DM) patients are at increased risk of cardiovascular diseases (CVDs). Several polymorphisms in the cholesterol ester transfer protein (CETP) gene have been reported.  The aim of this study was to determine the distribution and effect of the Taq1B polymorphism in the CETP gene on clinical and biochemical indicators of CVD risk in a population of endogamous-T2DM men. Methods: 102 men (57.5 ± 9.3 years-old) inhabitants of Santa Rosa del Conlara, San Luis, Argentina, were recruited and assigned into two groups (22 control and 80 T2DM). Further, these two groups were subdivided according their Taq1B CETP gene genotypes (i.e., B1B1, B1B2 and B2B2). Clinical and fasting-plasma biochemical indicators of CVD risk were measured and their association with the B1 allele was determined. Results: Compared to control, T2DM men had more central obesity, hypertension, atherogenic index, insulin resistance and poorly controlled diabetes. Compared to T2DM men having the B2 allele, those T2DM men having the B1 allele have increased risk of CVD as assessed by systolic blood pressure (156±16.0 vs 135.8±19.2, p=0.015), atherogenic index (6.15±1.3 vs 4.4±0.7, p=0.0008), HDL-c levels (38.9±5.3 vs 64.4±8.2, p