Biocompatible matrices for transdermal drug delivery applications

PUIG, J; GONZÁLEZ-GÓMEZ, MA; YÁÑEZ-VILAR, S; PIÑEIRO REDONDO Y; HOPPE, CE; RIVAS J.

Vigo

Encuentro; 3rd Annual Meeting Cinbio; 2019

Biomedical Research Centre - University of Vigo

Transdermal delivery system offers a non or minimally invasive, painless procedure and can be self-administrated.1,2 Stimulus-responsive systems for on demand release are desirable for thecontrolled release of active principles over long-term periods.3 PEG-based hydrogels are widely usedin a variety of biomedical applications due to their excellent biocompatibility and high hydrophilicity,including matrices for controlled release of biomolecules and scaffolds for regenerative medicine.4Magnetic responsive hydrogels can be remotely controlled upon exposure to an alternating magneticfield (AMF).5 A magnetic field can deform a hydrogel network containing magnetic nanoparticles andenhances the release of drug molecules.6In this work, a hydrogel that incorporates the magnetic nanoparticles (MNPs) and the active agentduring polymerization is described. An UV-photopolymerized PEG-based hydrogel is used as matrix.Dopamine is used as the model drug. The drug release behavior in response to an AMF is investigated.The possibility of reloading the dopamine by simple infiltration is explored.