Biochemical markers in umbilical cord blood as predictors of perinata complicationsl

SEBASTIAN GRUCCIO; MARÍA BEATRIZ DI CARLO; MARCELA PANDOLFO; GUSTAVO NEGRI; HILDA MALAMUD DE RUDA VEGA; MANUEL VAZQUEZ BLANCO; BEATRIZ PERAZZI

Journal of US-China Medical Science

David Publishing Company

Año: 2012 vol. 9 p. 562 - 568

1548-6648

Background: Inflammatory, metabolic and immunological disorders affecting the fetus in different ways commonly occurduring pregnancy. Disorders such as abortion, intrauterine growth restriction (IUGR), low birth weight and neonatal mortality areknown to occur in early life and cardiovascular and metabolic disease could occur in adult life. Objective: To analyze differentbiochemical parameters (BP) for the early detection of perinatal complications in maternal venous blood (MVB) and newborns?umbilical cord blood (UCB) from healthy mothers and mothers with underlying conditions or diseases associated with gestation.Materials-Methods: Samples from MVB (173) and UCB (173) were analyzed. Delivery was via cesarean section. Mothers andnewborns were classified into two groups: the control group (C-n = 64) and the pathological group (P-n = 109). Maternal diseases:diabetes, hypertension, anti-phospholipid syndrome, hyper/hypotiroidism, intrahepatic-cholestasis and genital infections. Newborndisorders: IUGR and/or fetal distress. BP:Glucose,urea,creatinine, uric acid, total bilirubin, proteins, albumin, transaminases(ALT/AST), alkaline phosphatase, gamma-glutamyltranspeptidase (GGT), creatine kinase, lactatedehydrogenase (LDH), iron, calcium,phosphorus, magnesium, sodium, potassium(K), chlorine, cholesterol, triglycerides, hsCRP were measured by recommendedmethods-Roche autoanalizer. Student?s and Mann Whitney tests were performed, p < 0.05. Results: -P newborns from P mothersshowed significant decrease in gestation weeks (GW) and newborn weight (NW) with respect to C newborns from C mothers (p: 0.001;0.01, respectively); significant increases in K, AST, LDH, GGT (p:0,005;0,03;0,03;0,02;respectively). -P mothers showed significantincrease in hsCRP (p: 0.02) with respect to C mothers. Conclusions: In P newborns from P mothers with respect to C, the decrease inGW and NW might be related to IUGR, a typical condition associated with these disorders; increases in K, AST, LDH, GGT would berelated to cellular destruction associated to maternal disorders and deficit in pulmonary development as a result of IUGR, respectively.The increase in hsCRP from P mothers with respect to C mothers could be associated to an inflammatory process. A future study with