INVESTIGADORES
PERAZZI Beatriz Elizabeth
artículos
Título:
New biochemical parameters in the differential diagnosis of ascetic fluids?.
Autor/es:
ANABELA ANGELERI; ADRIANA ROCHER; BEATRIZ CARACCIOLO; MARCELA PANDOLFO; LUIS PALAORO; BEATRIZ PERAZZI
Revista:
Gastroenterology Research
Editorial:
Elmer Press
Referencias:
Año: 2016 vol. 9 p. 17 - 21
ISSN:
1918-2805
Resumen:
Background: In the cases of ascitis, it is essential to determine theirorigin using the parameters obtained by the cytological and biochemicalexaminations. The aim of this study was to evaluate the usefulnessof different biochemical markers and the number of cells in the differentialdiagnosis of ascitic fluid (AF).Methods: One hundred ninety-one cases of AF were studied, whowere admitted to the hospital from January 01, 2009 to December 31,2014. One hundred fifty-two of them were included in the analysis,and the remaining 39 were excluded because they had more than oneassociated pathology, clotted or hemolyzed.Results: The more frequent etiologies of AF were the cirrhosis (29%),the infections (22%) and the neoplasies (19%). Other pathologiesreached 16%. Cutoff > 300 cells/mm3 detected the 78% of exudates.The AF/serum (S) of aspartate aminotransferase (AST) (> 0.5), lactatedehydrogenase (LDH) (> 0.6), proteins (PT) (> 0.5), cholesterol(COL) (> 0.4), and alanine aminotransferase (ALT) (> 0.5) correctlydetected 80%, 78%, 72%, 70% and 70% of the exudates, respectively.Conclusion: We proposed the utilization of a new cutoff of cellularcounting, major of 300/mm3, since it would allow improving the detectionof exudate ascites, without including the transudate ascites.AST AF/serum ratio (AF/S) showed the major usefulness in the differentiationand characterization of AF; LDH, proteins, cholesteroland ALT might be also acceptable in the above mentioned differentiation.The serum-ascites albumin gradient (SAAG) turned out to bea good marker of portal hypertension associated with cirrhotic processes.Creatine kinase (CK), alkaline phosphatase (ALP), amylase(AMI), total bilirubin (TB), triglycerides (TG) and glucose (GLU) didnot allow differentiating exudates from transudates.
