IBBEA 24401
INSTITUTO DE BIODIVERSIDAD Y BIOLOGIA EXPERIMENTAL Y APLICADA
Unidad Ejecutora - UE
artículos
Título:
Fluoxetine exposure disrupts food intake and energy storage in the cichlid fish Cichlasoma dimerus (Teleostei, Cichliformes)
Autor/es:
DA CUÑA, RODRIGO H.; LÓPEZ GRECO, LAURA; DA CUÑA, RODRIGO H.; LÓPEZ GRECO, LAURA; SGANGA, DANIELA E.; LO NOSTRO, FABIANA L.; SGANGA, DANIELA E.; LO NOSTRO, FABIANA L.; DORELLE, LUCIANA S.; REY VÁZQUEZ, GRACIELA; DORELLE, LUCIANA S.; REY VÁZQUEZ, GRACIELA
Revista:
CHEMOSPHERE
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 2020 vol. 238
ISSN:
0045-6535
Resumen:
Human pharmaceuticals are pollutants of special concern due to their widespread consumption over the last decades, their high persistence in the environment, and the reported alterations produced on nontarget organism. The antidepressant fluoxetine (FLX) exerts its effect by inhibiting serotonin (5-HT) reuptake at the presynaptic membrane, thus increasing brain serotonergic activity. In vertebrates, there is a clear inverse relationship between hypothalamic 5-HT levels and food intake, therefore we hypothesizedthat FLX would inhibit food intake, and in consequence alter energy metabolism in freshwater fish. The aim of this study was to analyze the effect of FLX on feeding behavior and energy storage of the cichlid fish Cichlasoma dimerus. Adult fish were intraperitoneally injected daily with 2 or 20 mg.g1 FLX or saline for a 5-day period, during which the 20 mg.g1 FLX-injected fish exhibited a marked reduction in food intake, consistent with a decrease in total body weight and total hepatocyte area observed at the end ofthe experiment. Although not statistically significant, a marked 50% decrease in glycogen and lipid content and an increase in protein levels in liver was observed for the 20 mg.g1 FLX dose. This was evidenced histochemically by a weak PAS positive reaction and an intense Coomasie Blue stain. Taken together, these results suggest that the SSRI antidepressant FLX produces an anorectic effect in adults of C. dimerus, which could alter normal physiological function and, in consequence, have a negative impact on fish growth, reproduction, and population success.
