Quercetin attenuates testicular oxidative stress associated with Metabolic Syndrome

RODRIGUEZ V; LUQUE E; DIAZ DE BARBOZA GE; MOINE L; MARTINI C; RIVOIRA M; SILVANO L; TOLOSA DE TALAMONI N,

Córdoba

Jornada; XXII Jornadas de Investigación Científica de la FCM-UNC; 2021

Facultad de Ciencias Médicas- Universidad Nacional de Córdoba

The Metabolic Syndrome (MS) generates oxidative stress (OS) altering the male fertility. Quercetin (Qc) supplementation could improve this condition due to its antioxidant properties. Objective: to clarify the mechanisms by which MS affects testicular tissue and to determine if these alterations are reversed by treatment with Qc. Four groups of male Wistar rats were used: Control (C, n: 5), C + Qc (n: 4, 50mg / kg / day, orally, 15 days), MS (n: 4, 10% fructose in water, 45 days) and MS + Qc (n: 4, SM 30 days plus 15 days with Qc treatment). The study time was 45 days. Body weight and abdominal circumference were measured and serum glucose, triglycerides, cholesterol, HDL-cholesterol and testosterone were measured. In epididymis samples, vitality, motility and number of spermatozoa were determined. Glutathione (GSH) and catalase activity (CAT) were quantified in the testis homogenates. The histology of the testes was analyzed with hematoxylin / PAS. ANOVA and Bonferroni were performed (significant differences at p