Multiparity dampened the neurobehavioral consequences of mother-pup separation stress in dams

AGUGGIA, JULIETA PAOLA; SUAREZ, M.; RIVAROLA, MARÍA ANGÉLICA

Palermo (Italia)

Exposici�n; Perinatal Origins of Neuropsychiatric Disorders: from molecular mechanism to therapeutic perspectives; 2019

University of Palermo, Italy

As we all know, in mammals, RE has three main stages ? Pregnancy, parturition and lactation ? all this step results in many hormonal, neuronal and behavioral changes necessary to ensure the offspring survival and growthAs soon as the pups born the mother displays a dramatic change in behavior some of the most important maternal behavior are pup linking and grooming, pup retrieval, nursing, nest building and maternal aggression. During this experience, the attachment relationship between mother and offspring is a potential Benefit for both. In the female chances occur in nervous circuits and behaviors that are not directly related to maternal behavior BUT involve A BENEFITIAL EFFECTS ON cognition, affect and responses to stress.On besides, there is a consensus that RE (primiparous and multiparous) itself impact in the dam giving it a greater resilience to stress, better memory abilities, decreased anxiety.Nevertheless, as far as we know no study has assessed whether reproductive experience affects the response to a chronic stress such as repeated pup separation. So. Our main objective is to analyze whether reproductive experience (number of pregnancy and parturition) affects the behavioral response to an environmental stress as the early mother-pup separation, and study possible neuronal underlying mechanisms.