Impact of metabolic síndrome on murine fetal programming.

TORRES P; MARTINI AC; GERBALDO V; JONES XM; LUQUE EM; RAMÍREZ N; ARJA A

Córdoba

Jornada; XX Jornada de Investigación de la Facultad de Ciencias Médicas; 2019

In Argentine, the metabolic syndrome (MS) is a highly prevalent pathology (30%),even during pregnancy. There exist several studies that investigate maternal malnutrition (hypo/ hypernutrition) on offspring development, showing that perinatal nutritional challenges exert long-lasting consequences in the development and reproductive function of the offspring. It remains unknown, if MS exerts similar effects. Using a rat model of induced MS, we aim to investigate whether this pathology is a reproductive fetal programmer.Female Wistar rats (60 days) were randomly divided into two groups: a) controls (C): pelleted chow + water or, b) MS: pelleted chow + 10% fructose (v/v) in water, which is a validated MS inductor protocol. Treatment was applied from 4 weeks before intercourse to weaning of the offspring (postnatal day 21).MS was verified in an initial group of dams (5 dams/treatment) with statistically higher values (p