IMMUNE-RELATED ADVERSE EVENTS INDUCED BY CANCER IMMUNOTHERAPIES. BIG DATA ANALYSIS OF 13,051 CASES (IMMUNOCANCER INTERNATIONAL REGISTRY)

MARIE KOSTINE; CLIFTON BINGHAM; THIERRY SCHAEVERBEKE; JAN LEIPE; ALEJANDRA FLORES-CHÁVEZ; GUSTAVO CITERA; MERAV LIDAR; DAVID LIEW; PHILIPPE GUILPAIN; YASUNORI SUZUKI; VIRGINIA FERNANDES MOÇA TREVISANI; NAOTO AZUMA; XAVIER MARIETTE; RAMOS CASALS MANUEL; LEONARD CALABRESE; TIMOTHY R. RADSTAKE; JACQUES-ERIC GOTTENBERG; CASSANDRA CALABRESE; BELCHIN KOSTOV; EVA AGUILAR; BENJAMIN FISHER; RUSSELL BUCHANAN; DEBASHISH DANDA; SAADETTIN KıLıÇKAP; SONJA PRAPROTNIK; BERKAN ARMAGAN; OLIVER LAMBOTTE; MARIA SUAREZ-ALMAZOR; CHIARA BALDINI; HENDRIK SCHULZE-KOOPS; PILAR BRITO-ZERÓN; SOLEDAD RETAMOZO; MICHAEL RICHTER; JEAN-MARIE MICHOT; MARTE SCHRUMPF-HEIBERG; PETER OLSSON; GABRIELA HERNANDEZ-MOLINA; ILDIKO FANNY HORVÁTH; MUNTHER KHAMASHTA

Madrid

Congreso; EULAR 2019 ? Annual European Congress of Rheumatology; 2019

The European League Against Rheumatism (EULAR)

Background: The ImmunoCancer International Registry (ICIR) is a BigData-Sharing multidisciplinary network composed by 39 specialists inRheumatology, Internal Medicine, Immunology and Oncology from 18countries focused on immune-related adverse events (irAEs) related tocancer immunotherapies (CIs).Objectives: To analyse the worldwide scenario of irAEs associated withthe use of CIs in this Century.Methods: The first objective of the ICIR has been the development of asystematic literature review crossing CIs terms with immune diseasesdefined according to MedDRAVR 15.0.Results: The cumulated number of cases per year of irAEs hasincreased exponentially, with 12,648 patients who developed 13,051 irAEsreported until Dec 31, 2018:: Combined CIs were used in 1962 (16%) patients, checkpoint inhibitors in 7099(66%, overwhelmingly CTLA4 and PD1 inhibitors) and Tyrosine Kinase inhibitorsin 3327 (31%); ipilimumab, nivolumab and pembrolizumab were associated withnearly 60% of reported cases. Organ-specific classification of irAEs is summarized in the figure:The Top10 irAEs included enterocolitis (18%), pneumonitis (12%), thyroiditis (11%), myocarditis (6%), myositis (5%), hypophysitis (5%), hepatitis(5%), neuropathy (4%), adrenal (3%) and joint involvement (3%). MostirAEs are organ-specific symptoms not fulfilled criteria of systemic/rheumatic diseases.Conclusion: More than 13,000 cases of irAEs triggered by CIs havebeen reported, with the organ-specific autoimmune damage of the endocrine, digestive and pulmonary systems accounting for 70% of the totalreported irAEs.