PHENOTYPE OF BIOPSY-PROVEN PATIENTS WITH PRIMARY SJÖGREN SYNDROME LACKING RO AUTOANTIBODIES: HIGH FREQUENCY OF DRYNESS SYMPTOMS WITH LOW SYSTEMIC ACTIVITY (BIG DATA SJÖGREN PROJECT)

RETAMOZO SOLEDAD; I FANNY HORVÁTH; LI X; DANDA D; HERNANDEZ-MOLINA GABRIELA; SK KWOK; SENE, DAMIEN; RISCHMUELLER, MAUREEN; ISENBERG, DAVID; ACAR-DENIZLI, NIHAN; NORDMARK GUNNEL; RASMUSSEN ASTRID; GIACOMELLI ROBERTO; BALDINI CHIARA; BOMBARDIERI, MICHELE; QUARTUCCIO, LUCA; PASOTO, SG; ARMAGAN BERKAN; MOREL, JACQUES; KVARNSTROM, MARIKA; MARIETTE, XAVIER; GERLI ROBERTO; MANDL THOMAS; VALIM VALERIA; F NG; BOOTSMA, HENDRIKA; SEROR R; DEVAUCHELLE-PENSEC, VALERIE; GOTTENBERG JE; FERNANDES MOÇA TREVISANI V; PRIORI ROBERTA; GHEITA TA; KRUIZE AA; VOLLENVEIDER, CRISTINA; PRAPROTNIK SONJA; RAMOS-CASALS, MANUEL; SOLANS ROSER; SUZUKI, YASUNORI; WILAND P; NAKAMURA T; HOFAUER, BENEDIKT; HAMMENFORS DANIEL; ATZENI, FABIOLA; CONSANI-FERNÁNDEZ, S; BRITO-ZERÓN, PILAR

Madrid

Congreso; EULAR: Annual European Congress of Rheumatology; 2019

EUROPEAN LEAGUE AGAINST RHEUMATISM (EULAR)

Methods: The International Big Data Sjögren Project was designed in 2014 to take a ?high-definition? picture of the primary SjS at diagnosis (2002 criteria) by merging international databases. 2716 FLS+/Ro- patients were compared with 8315 Ro+ patients Results: FLS+/Ro- patients were predominantly White (82% vs 77%), had a higher frequency of oral (97% vs 92%) and ocular (95% vs 91%) dryness, a lower frequency of ANA (60% vs 87%), hypocomplementemia (13% vs 23%), rheumatoid factor (26% vs 56%), cryoglobulins (5% vs 9%), a lower mean ESSDAI score (4.6 vs 6.6), and a lower systemic activity in the constitutional, lymphadenopatic, glandular, cutaneous, renal, hematological and biological domains (p