Differentiated Phenotypes at Diagnosis of Sarcoidosis According to the Scadding Classification: Analysis in 1230 Patients

BRITO ZERON PILAR; GUADALUPE FRAILE; BEGOÑA DE-ESCALANTE; JOEL CHARA-CERVANTES; JOSE SALVADOR GARCIA MORILLO; MIRIAM AKASBI; GLORIA DE LA RED BELLVIS; ENRIQUE PERAL GUTIÉRREZ DE CEBALLOS; SERGIO RODRÍGUEZ FERNÁNDEZ; A. ROLO; INMACULADA OJEDA; MARÍA PENADÉS VIDAL; MARTA PÉREZ-DE-LIS; B. GRACIA-TELLO; CARLES TOLOSA VILELLA; RAMOS CASALS MANUEL; ROBERTO PÉREZ-ALVAREZ; CARLOS FEIJOO MASSÓ; RICARDO GÓMEZ DE LA TORRE; ANA ALGUACIL; FRANCISCO-JAVIER RASCÓN; EVA FONSECA AIZPURU; JOSÉ LUIS CALLEJAS; CRISTINA SOLER I FERRER; GRACIA CRUZ CAPARRÓS; ALBERTO GATO DIEZ; ANGEL ROBLES; BORJA DE-MIGUEL; XAVIER BOSH; CARMEN YLLERA GUTIÉRREZ; A. PEREZ-GONZALEZ; RETAMOZO SOLEDAD; LUCIO PALLARÉS; BELCHIN KOSTOV; GONZÁLEZ-GARCÍA A; MIGUEL LOPEZ-DUPLA; M. PÉREZ-CONESA; PATRICIA PEREZ GUERRERO; MARIONA BONET; EVA CALVO BEGUERIA; J. F. GÓMEZ-CEREZO; BLANCA PINILLA; CÉSAR MORCILLO; M. J. VIVES; MOISÉS DE VICENTE; A. GONZÁLEZ-GARCÍA; M. PEDROSA; ANTONI SISÓ-ALMIRALL

Chicago

Congreso; 2018 ACR/ARHP Annual Meeting; 2018

American Collage of Rheumatology

Background/Purpose: To analyse the correlation between Scadding radiological stages and the main phenotypic features at diagnosis (epidemiology, clinical patterns at presentation, extrathoracic disease and need for initial systemic therapy) in one of the largest cohorts of patients with sarcoidosis reported from Southern Europe.Methods: The SARCOGEAS-Study Group was formed in 2015 including a multicenter database of consecutive patients diagnosed with sarcoidosis according to the WASOG 1999 criteria. Extrathoracic disease at diagnosis was defined according to the 2014 WASOG organ assessment instrument and the extrathoracic clusters proposed by Schupp et al.Results: 1230 patients were finally analysed (712 women, mean age 47.3 yrs). Scadding radiologic stage at diagnosis consisted of stage 0 in 98 (8%) patients, stage I in 395 (32%), stage II in 500 (41%), stage III in 195 (16%) and stage IV in 42 (3%) patients. Epidemiologically, age at diagnosis was clearly linked with the Scadding stage, with younger mean ages being reported for stages I and II (p=0.001). With respect to extrathoracic disease, the highest frequencies of the organ-by-organ WASOG involvements are reported in stage 0 (skin, liver, spleen, ENT, nervous system and bone marrow), stage I (salivary glands, bone/joint) and stage IV (extra-thoracic lymph node, eye, kidney, calcium-vitamin D and heart) (FIGURE 1). The three SchappÕs extrathoracic clusters are overrepresented in stage 0. Patients with stage IV had the highest frequencies of both need of and aggressiveness of therapy, while patients with stage I had the lowest frequencies. Pulmonary fibrosis was related to a higher mean age at diagnosis (55 vs 47 yrs, p