Diagnostic Performance of Labial Salivary Gland Biosy, Serological and Clinical Data in Sjogrens Syndrome. in Argentinian Multicenter

DIEGO BAENAS; JUAN PABLO PIROLA; CEBALLOS RECALDE FLAVIA; PRISCILA SERRAVALLE; FRANCISCO CAEIRO; JANET FLORES; RETAMOZO SOLEDAD; NADIA RISCANEVO; ALEJANDRO ALVARELLOS; SERGIO PAIRA; MARIA JEZABEL HAYE SALINAS; NADIA BENZAQUÉN; ANA C. ALVAREZ; ALBERTO ORTIZ

Chicago

Congreso; 2018 ACR/ARHP Annual Meeting; 2018

American Collage of Rheumatology

Background/Purpose:Labial salivary gland biopsy (LSGB) is a safe and minimally invasive procedure used in the diagnostic evaluation of Sjogren?s Syndrome (SS). The objectives of this study are: to describe the demographic, clinical and histological characteristics of patients submitted for LSGB; to examine the usefulness of this procedure as a diagnostic tool for SS; to assess the association between histological findings and antibodies.Methods: An observational, analytical, cross-sectional study was performed between June 1996 and July 2017. Patients with SS were classified according the AECG-2002 and ACR-2012 criteria. Grades III and IV biopsy of the Chisholm and Mason´s classification/focus score ≥1 were considered positive. Data was analyzed using the statistical package SPSS 21.Results: 1101 patients were included, 91 % females. The mean age was 52 ± years(range18?86). SS was diagnosed in 413 (37.5%) patients. 34% of the biopsies were positive. Table 1 shows the clinical characteristics and complementary studies in patients with nonspecific dryness syndrome (No-SS) and SS. In bivariate analysis there was an association between antiRo, ANA and RF antibodies and LSGB. In multivariate analysis the significance for anti-Ro (OR: 6.33; 95% CI 3.22 to 12.15), ANA (OR: 3.26; 95% CI 2.15 to 4.94) and RF (OR: 3.05; 95% CI 2.04 to 4.56) was maintained.Conclusion: LSGB is a simple, safe, and useful tool for the diagnosis of Sjögren?s syndrome. It exhibits an adequate balance between sensitivity, specificity, positive and negative predictive value. Antibodies showed a significant association with a positive LSGB with low sensitivity for SS screening but high specificity. LSGB has a great value in ?seronegatives patients?.