Autoimmune Diseases in Catalonia: A Population Based Study Using a Public Big Data Program

BELCHIN KOSTOV; FLORES-CHAVEZ ALEJANDRA; ANTONI DEDÉU BARALDÉS; SISO ALMIRALL ANTONI; RETAMOZO SOLEDAD; BRITO ZERON PILAR; RAMOS CASALS MANUEL; MARTÍNEZ CARBONELL ELISENDA; S. GONZÁLEZ-MARTÍNEZ; JAUME BENAVENT ÀREU

Chicago

Congreso; 2018 ACR/ARHP ANNUAL MEETING; 2018

American College of Rheumatology

Background/Purpose: To analyse the prevalence of autoimmune diseases (ADs) in Catalonia byusing a public big data program (Public Data Analysis for Health Research and Innovation Program,PADRIS)Methods: We used the health insurance database of the Catalan National Health Insurance (CNHI)which includes all catalan insured population in 2016 (7,483,761 inhabitants). ADs were identifiedaccording to the corresponding International Classication of Diseases, Ninth Revision, ClinicalModification (ICD-9-CM) codes. A total of 33 autoimmune diseases were analysed classifed in 4 maincategories: rheumatic, systemic, organ-specific and immunodeficiency/autoinflammatory. Theprevalence of ADs was calculated as the number of ADs patients divided by the total CNHIbeneficiaries in the same year (rate per 100,000 persons, 95% confidence intervals -CI-).Results: In Catalonia, the overall prevalence of ADs was 1,202 per 100,000 persons (95%CI 1,194-1,209); the prevalence was 1,455 (95%CI 1,443-1,467) in women and 939 (95%CI 929-949) in men. ADswere identified as organ-specific (43%), systemic (33%), rheumatic (23%) and immunodeciency/autoinflammatory (1%) autoimmune diseases. The Top Ten of ADs with thehighest prevalence rates included cutaneous psoriasis (282 cases per 100,000), rheumatoid arthritis(178 cases per 100,000), polymyalgia rheumatic (98 cases per 100,000), spondyloarthropathies (92cases per 100,000), vasculitis (91 cases per 100,000), systemic lupus erythematosus (68 cases per100,000), Sj?gren?s syndrome (59 cases per 100,000), celiac disease (58 cases per 100,000), multiplesclerosis (57 cases per 100,000) and psoriatic arthritis (43 cases per 100,000). In 26 (79%) of the 33ADs, the female:male ratio was higher than 1; the highest ratios were reported for Sj?gren?ssyndrome (10.5), primary biliary cholangitis (5.8), SLE (5.4), systemic sclerosis (3.4) and rheumatoidarthritis (2.6). We found a significant geographical variation in the prevalence of the main diseases.Conclusion: Nearly 90,000 catalans are classified as having an autoimmune disease, representing aprevalence of 1.2% of the total population in Catalonia, a rate that reaches 1.5% in women. We founda different territorial distribution of the main diseases, suggesting a significant influence ofgeographically-driven determinants in the prevalence of autoimmune diseases.