A North-South worldwide gradient in systemic activity of primary Sjögren syndrome: increased severe disease in patients from Southern countries

RETAMOZO SOLEDAD; MARGIT ZEHER; XIAOMEI LI; DEBASHISH DANDA; GABRIELA HERNANDEZ-MOLINA; SEUNG-KI KWOK; DAMIEN SENE; MAUREEN RISCHMUELLER; DAVID ISENBERG; GUNNEL NORDMARK; TAKASHI NAKAMURA; BENEDIKT HOFAUER; DANIEL HAMMENFORS; FABIOLA ATZENI; BRITO ZERON PILAR; W. FAI NG; RAPHAELE SEROR; JACQUES-ERIC GOTTENBERG; ROBERTA PRIORI; AIKE A. KRUIZE; SONJA PRAPROTNIK; ROSER SOLANS; YASUNORI SUZUKI; PIOTR WILAND; HENDRIKA BOOTSMA; VALERIE DEVAUCHELLE-PENSEC; NIHAN ACAR-DENIZLI; VIRGINIA FERNANDES MOÇA TREVISANI; ASTRID RASMUSSEN; TAMER A GHEITA; CHIARA BALDINI; CRISTINA VOLLENVEIDER; LUCA QUARTUCCIO; BERKAN ARMAGAN; MARIE WAHREN-HERLENIUS; ELENA BARTOLONI; THOMAS MANDL; VALERIA VALIM; GUADALUPE FRAILE; ROBERTO GIACOMELLI; MICHELE BOMBARDIERI; SANDRA G. PASOTO; JACQUES MOREL; RAMOS CASALS MANUEL

Amsterdam

Congreso; EUROPEAN LEAGUE AGAINST RHEUMATISM (EULAR); 2018

EULAR

Objective. To analyse the influence of geolocation on the clinical systemic presentation of primary Sjögren syndrome (SjS) at diagnosis.Methods. The Big Data Sjögren Project Consortium is an international, multicentre registry created in 2014. The centers share a harmonized data architecture and conduct cooperative online efforts in order to refine collected data under the coordination of a big data statistical team. Inclusion criteria were the fulfilment of the 2002 classification criteria. By January 2018, the participant centres had included 10475 valid patients from 22 countries. Centers were first classified by continent, with an additional north-south sub-classification according to latitude in continents including patients from > 1 country (latitude > or < 50?N in Europe, equator > or < in America and latitude > or < 30?N in Asia). Systemic involvement at diagnosis was retrospectively classified and scored according to the ESSDAI.Patients. The highest baseline ESSDAI scores were homogeneously reported from Southern countries in Europe (7.2 vs 4.6 in Northern Europe p