Influence of epidemiology and ethnicity on systemic expression of primary sjogren syndrome in 9974 patients

FAI NG W; SEROR, RAPHAELE; GOTTENBERG, JACQUES- ERIC; PRIORI ROBERTA; ARMAGAN BERKAN; WAHREN-HERLENIUS MARIE; BARTOLONI ELENA; THOMAS MANDL; VALERIA VALIM; GUADALUPE FRAILE; ROBERTO GIACOMELLI; MICHELE BOMBARDIERI; SANDRA G. PASOTO; JACQUES MOREL; ACAR-DENIZLI, NIHAN; RAMOS CASALS MANUEL; RASMUSSEN ASTRID; BALDINI CHIARA; QUARTUCCIO LUCA; ARMIGER N; KWOK, SEUNG-KI; SENE, DAMIEN; RISCHMUELLER, MAUREEN; DAVID ISENBERG; GUNNEL NORDMARK; TAKASHI NAKAMURA; BENEDIKT HOFAUER; RETAMOZO SOLEDAD; DANIEL HAMMENFORS; MARGIT ZEHER; FABIOLA ATZENI; XIAOMEI LI; BRITO ZERON PILAR; DANDA, DEBASHISH; HERNANDEZ-MOLINA GABRIELA; KRUIZE AIKE; PRAPROTNIK SONJA; ROSER SOLANS; YASUNORI SUZUKI; PIOTR WILAND; HENDRIKA BOOTSMA; VALERIE DEVAUCHELLE-PENSEC; VIRGINIA FERNANDES MOÇA TREVISANI; TAMER A GHEITA; CRISTINA VOLLENVEIDER

Amsterdam

Congreso; EUROPEAN LEAGUE AGAINST RHEUMATISM (EULAR); 2018

EULAR

Objective. To analyse the influence of epidemiology and ethnicity on the clinical systemic presentation at diagnosis of primary Sjögren syndrome (SjS).Methods. Following a worldwide data-sharing cooperative merging of international clinical SjS databases, the Big Data Sjögren Project Consortium was created in 2014 as an international, multicentre registry of patients fulfilling the 2002 classification criteria. By January 2018, the participant centres had included 10475 valid patients from 22 countries. The main epidemiological variables analysed in this study included age at diagnosis, gender and ethnicity following FDA definitions (77% White, 14% Asian, 6% Hispanic, 1% Black/African American, 2% others). Systemic involvement at diagnosis was retrospectively classified and scored according to the ESSDAI, clinESSDAI and DAS.Patients. Male gender was homogeneously associated with an enhanced systemic activity at diagnosis including a higher mean ESSDAI (8.0 vs 5.9, p