Intake and dietary sources of fatty acids omega 3 6 and 9 and markers of cardiometabolic risk in patients with abdominal adiposity: preliminary results

DEFAGO MD ; PASQUALINI ME; PEROVIC NR ; FLORES D; CARRIZO L; MARCHIORI GN ; ERASO A

Buenos Aires

Congreso; IUNS 21st International Congress of Nutrition; 2017

Sociedad Argentina de Nutrición

Background and objectives:abdominal adiposity is associated with metabolic risk profile such asdyslipidemia and low grade systematic inflammation. Dietary unsaturated fattyacids (FA) could influence metabolic alterations associated with visceraladipose tissue. We aimed to analyze foodsources of n-3 and n-6 and n-9 FA and their association with serum lipidprofile, hyperglycemia and high-sensitivity C-reactive protein (hs-CRP) inpatients with abdominal adiposity. Methods: observational, correlationalstudy. Sample was conformed by 47 adults between 40-80 years old, both sexes,with central adiposity determined by waist circumference (WC), attended inCardiology Division, National Hospital of Clinics, Córdoba, Argentina, 2014-2016. Medical history and validatedfood frequency questionnaire were applied. Food information was processed usingthe Interfood v.1.3. nutritional softwareFA food sources were classified in: n-9 FA (olive oil, avocado and olives), 20:4n-6 FA (red meat, chicken and eggs), 18:2 n-6 FA (corn, soybean, sunflower andmixed oil), 20:5 and 22:6 n-3 FA (fish and seafood), and 18:3 n-3 FA (nuts andseeds). Anthropometric measures, serum lipid profile (total cholesterol, LDL-col,col-HDL and triglycerides), glycemia and hs-CRP were determined. Linealregression adjusted by age, sex, total energy intake, body mass-index (BMI),smoking, and physical activity were development to analyze associations betweenfood source of FA and biochemical markers.Results: the sample was conformed by 51% ofmen (age 60.4 ± 9.8 years) and 49% women (age 57.1 ± 9.3 years). 40% showed overweightand 41% obesity. According to WC, 26% had high-risk and 74% very high risk. Mediumof total cholesterol was 185.4 ± 37.3 mg/dL, LDL-c 108.6 ± 30.6 mg/dL, HDL-c 50.6 ±13.1 mg/dL, triglycerides 145.1 ± 65.2 mg/dL, glycemia 113.1 ± 26.2 mg/dL, and PCR-us 4.0 ± 2.5 mg/L. About dietary intake, the consumption for n-9food was 13.1 ± 12.6 g/day, 20:4 n-6 FA 226,4 ± 122,6 g/day, 18:2 n-6 FA 22.4 ±16.2 g/day, 20:5-22:6 n-3 FA 13.5 ± 14.2 g/day and 18:3 n-3 FA 11.6 ± 18.6g/day. Significant positive association was observed between intake of 20:4 n-6FA and triglycerides concentration (β=0,25; p=0,04) and between 20:5-22:6 n3 FAand HDL-c (β=0,35; p=0,03).Conclusions:thesepreliminary results show the influence of diet in lipid profile. Dietaryintervention are an important tool in patients with cardiometabolic riskfactors. Conflictof interest Disclosure: Authorshave no conflicts of interests.