NEONATAL HIGHER C-REACTIVE PROTEIN LEVELS ARE ASSOCIATED WITH LOWER WEIGTH AND HEIGTH AT 12-MONTHS CORRECTED AGE IN VERY PRETERM INFANTS

CERUTTI M; CUESTAS E; RIZZOTTI A; AGUILERA B

Buenos Aires

Otro; 55ª Reunión Anual Sociedad Latinoamericana de Investigación Pediátrica.; 2017

Sociedad Latinoamericana de Investigación Pediátrica

NEONATAL HIGHER C-REACTIVE PROTEIN LEVELS ARE ASSOCIATED WITH LOWER WEIGTH AND HEIGTH AT 12-MONTHS CORRECTED AGE IN VERY PRETERM INFANTS Eduardo Cuestas(a,b), María Belén Aguilera(b), Manuel Cerutti(b) and Alina Rizzotti(b). (a) Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba, Consejo Nacional de Investigaciones Científicas y Técnicas (INICSA-UNC-CONICET). Córdoba, Argentina. (b) Departamento de Pediatría y Neonatología. Hospital Privado Universitario de Córdoba. Instituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC). Córdoba, Argentina. Background: An association between neonatal systemic inflammation (SI) and postnatal growth has not been reported. We hypothesized that infants exposed to SI would show poor postnatal growth. Objective: To determine whether a neonatal marker of SI was associated with poor postnatal growth among VPI at 12 months corrected age (CE). Methods: We studied singleton, AGA infants, ≤32 weeks´ GA and BW ≤1.5 kg without congenital malformations, enrolled since 2006-2016. Weight, length and head circumference were recorded at birth and at 12 months CE. Standardized Z-scores for weight (WZ), length (LZ) and head circumference (HCZ) at 12 months CE were calculated and we estimated their association with mean CRP sampled on days 1-3-7-14-28 of life. Multiple linear regression and stratified analysis were performed. Results: 96 infants, 38 (38.8%) males, with 29.2±2.5 wks´ GA, 1,155±0,312 Kg BW, -0.42±0.79 WZ, 0.51±0.78 LZ and 0.43±0.78 at birth were studied. The mean neonatal CRP was 2.5±3.8 mg/L. Growth failure was present in 15 (15,6%) infants at 12 months CE. Decreases in WZ and LW (β -0.052±0.023; p 0.028 and β -0.074±0,024; p 0.003 respectively) were significantly associated with higher mean CRP. HCZ was not significantly associated with mean CRP levels (β 0.009±0,021; p 0.680). The association remained significant in infants with prenatal corticosteroids exposure and neonatal complications (bronchopulmonary dysplasia, neonatal sepsis and necrotizing enterocolitis) from the non-exposed groups. Conclusions: SI is associated with poor postnatal growth. Serial CRP may be useful marker for identifying infants at risk for postnatal growth failure.