Weight and redox effect of infusive phytoextracts on overweight female mice treated for fifteen days

MIRANDA A; LEONANGELI S; CITTADINI MC; ALBRECHT C; CANALIS AM; SORIA EA

Córdoba

Congreso; Reunion Internacional de Ciencias Farmaceuticas; 2014

Extracts from native plants contain phenolic compounds and can affect animal organism and tissue redox response. There are many attempts to discover plant-based drugs which will be useful for the treatment of chronic metabolic diseases. Thus, our aim was to evaluate body weight and redox markers in tissues of overweight female mice. Animals were treated orally for 15 days with 100 mg/Kg/d of Ilex paraguariensis A. St.-Hil. (IP), Aspidosperma quebracho-blanco Schltdl. (AQB) or Lantana grisebachii Stuck. (LG) (aqueous extracts from plant infusion at 95°C), and respect to controls (C). Then, phenolic bioavailability was assessed in brain and spleen using a fast blue bb-based technique. Statistics included ANOVA and Spearman correlation (SC). For the three extracts, body weight gain was inversely correlated to phenolic concentration in brain (telencephalon SC=-0.70; diencephalon SC=-0.71, p